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News :: 04/01/2019

Breath analysis - Simultaneous measurement of CH4 and CO2

Gastrointestinal diseas diagnosed with breath analysis

Axetris, Laser Gas Detection, Leister Corporate

Axetris’ OEM gas sensing modules are able to measure both methane and carbon dioxide simultaneously. This makes them particularly suited for medical applications where the analysis of patient’s exhaled air is used to support the diagnosis of various gastrointestinal diseases, e.g. food intolerance.

Brief application description

The analysis of exhaled breath air is an effective non-invasive technique to diagnose food intolerances such as lactose intolerance, malabsorption of fructose, sucrose and sorbitol as well as diseases such as the Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth (SIBO) or the infection with Helicobacter Pylori (urea breath test UBT).

The breath analysis based diagnosis of above mentioned diseases is performed by measuring the concentration and ratio of specific gas components such as hydrogen (H2), methane (CH4), carbon dioxide (CO2) or ammonia (NH3).

Hydrogen is produced in the intestinal lumen by bacteriological breakdown of carbohydrates and its detection helps clinicians to understand digestive problems.

Methane provides important insights into the performance of the carbohydrate metabolism and significant levels of methane can suggest indigestion and are a possible indicator of fructose or lactose intolerance. Axetris’ gas sensing technology is capable of measuring methane with unprecedented precision and selectivity at trace levels.

Carbon dioxide is considered an indicator for various infections as well as liver malfunction and excessive bacteria growth. Moreover, carbon dioxide is a quality indicator, indicating whether the patient is taking sufficiently long and deep breaths during the test phase, thus to ensure the samples used for analysis are alveolar. Low levels of carbon dioxide suggest shortness of breath. Carbon dioxide is used as a reference to derive the amount of exhaled air that has been measured by the sensor and is used as a reference to determine the correct ratio of all breath air constituents.

The above mentioned constituents in exhaled human breath air can be detected and measured with Tunable Diode Laser Spectroscopy (TDLS), where the high selectivity and the ability to measure at sub-ppm levels are well-known technology-specific strengths compared to other approaches.

Our offering as OEM partner

  • In-depth TDLS technology and application expertise
  • Close collaboration and partnership from initial feasibilities through product design, launch and lifecycle management.

Major benefits of TDLS technology

  • High selectivity and precision to target gases
  • Detection limits down to sub-ppm level
  • Optical, contact-less laser-based measurement
  • Low cost of ownership, high reliability in the field
  • Long lifetime

Our LGD Compact platform

Size: when it comes to integrate the sensing module in a benchtop device or a portable instrument, size becomes a critical customer requirement. The small footprint design of our LGD Compact platform is well-suited to fulfill those needs.

Performance: the increasingly demanding performance requirements clearly indicates the need for increased performance such as lower detection limits, increased measuring speed, multi-range and dual-gas measurement capabilities.

Affordability: with the cost-efficient design of our LGD Compact product family, we aim to popularize TDLS technology and make it more affordable for your applications.

Axetris LGD Compact

LGD Compact-A module

Download the whole application note Simultaneous measurement of CH4 and CO2 here.

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